merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5084P,Anti-Dopamine D2 Receptor Antibody

  • merck millipore,默克密理博,AB5084P,Anti-Dopamine D2 Receptor Antibody

    产品名称：Anti-Dopamine D2 Receptor Antibody
    产品型号：AB5084P
    This Anti-Dopamine D2 Receptor Antibody is validated for use in ELISA, IH, IP, WB for the detection of Dopamine D2 Receptor.

    merck millipore,默克密理博,AB5084P,Anti-Dopamine D2 Receptor Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5084P,Anti-Dopamine D2 Receptor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, H, M, RWB, ELISA, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5084P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Dopamine D2 Receptor Antibody
    Alternate Names
    • Dopamine D2 receptor
    背景信息 The Dopamine D2 Receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. 2 isoforms are reported for the D2 Dopamine Receptor, Isoform 1 and isoform 2 which are expressed in the pituitary and brain; Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.
    产品信息
    格式 Affinity Purified
    控制
    • Monkey brain tissue, rat brain lysate
    演示 Purified rabbit polyclonal liquid in PBS with 0.1% BSA and 0.05% sodium azide.
    应用
    应用 This Anti-Dopamine D2 Receptor Antibody is validated for use in ELISA, IH, IP, WB for the detection of Dopamine D2 Receptor.
    主要应用
    • Western Blotting
    • ELISA
    • Immunohistochemistry
    应用说明 Western blot:
    1-10 µg/mL (Chemiluminescence technique) The predicted size of D2 is approximately 50 kDa. However, additional bands at approximately 68 and 100 kDa, and others are typically seen in various tissues (Boundy et al. 1993; Sakata et al. 1992; Farooqui et al. 199; Farooqui & Prasad 1992, BBRC; Brock et al. 1992; Farooqui & Prasad 1992, Life Sci). Approximately 100-400 µg of membrane protein/lane should be loaded to visualize various bands.

    Immunohistochemistry:
    2-10 μg/mL on paraformaldehyde fixed sections on a previous lot.
    Immunohistochemistry:
    1-20 µg/mL on paraformaldehyde fixed sections.

    Immunoprecipitation:
    1-10 μg/mL using 100-400 μg of protein on a previous lot. An antibody made to this epitope has been shown to immunoprecipitate both the long and short forms (2).

    ELISA:
    0.5-1.0 μg/mL (1 μg/mL immunogen peptide (Catalog number AG221)/well) of a previous lot was used on ELISA.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 28 amino acid peptide sequence from the human D2 receptor within the cytoplasmic
    loop #3.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Specific for Dopamine Receptor D2 short and long form. Dopamine D2 receptor is known to exist in the short (D2S) and the long (D2L) forms that are encoded by splice variants of a single gene and differ only by the presence of an additional 29 amino acid in the intracellular, cytoplasmic loop 3 (1). D2L receptor is a 446 aa, G-protein coupled and transmembrane receptor protein (2). The immunogen peptide shows no significant homology with other dopamine receptors (D1 and D3-D5).
    品种反应性 MonkeyHumanMouseRat
    Species Reactivity Note Human, mouse, rat and monkey.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000795.2
    Entrez基因汇总 This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
    基因符号
    • D2R
    • DRD2
    • D2DR
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P14416
    UniProt汇总 FUNCTION: SwissProt: P14416 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
    SIZE: 443 amino acids; 50619 Da
    SUBUNIT: Interacts with GPRASP1, neurabin-2 and CLIC6 (By similarity). Interacts with CADPS and CADPS2.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    DISEASE: SwissProt: P14416 # It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia. & Defects in DRD2 are associated with myoclonus dystonia (MD) [MIM:159900]; also known as myoclonic dystonia, alcohol- responsive dystonia and dystonia-11 (DYT11). MD is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
    SIMILARITY: SwissProt: P14416 ## Belongs to the G-protein coupled receptor 1 family
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on human brain lysates.

    Western Blot Analysis: 1:1000 dilution of this lot detected Dopamine Receptor D2 on 10 μg of human brain lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5084P,Anti-Dopamine D2 Receptor Antibody

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