- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,AB4254,Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular
产品名称：Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular
产品型号：AB4254
This Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2.
merck millipore,默克密理博,AB4254,Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IH(P) Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB4254 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular Alternate Names - PAR-2
背景信息 The Proteinase-activated receptor 2 (PAR2) is a member of the proteinase-activated receptor subfamily. It is activated through proteolytic exposure of an occult tethered ligand by trypsin and trypsin-like proteases. This is in contrast to other members of the subfamily which are activated by the protease thrombin. PAR2 has been implicated in acute inflammatory response, asthma, and pain transmission. PAR2 expression has been documented in the periphery. ESTs have been isolated from adrenal, brain, breast, heart/melanocyte/uterus, kidney, lung, and vessel libraries. 产品信息 格式 Affinity Purified 演示 Peptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide 应用 应用 This Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2. 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to a sequence within the N-terminal extracellular domain of human PAR2. The immunogen has 70% homology with mouse and 60% homology with rat. 表位 N-terminal, extracellular 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes human PAR2. The specificity of this antibody has been confirmed by IHC staining of human pancreas. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005242.3
Entrez基因汇总 Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. 基因符号 - GPR11
- F2RL1
- PAR-2
- PAR2
UniProt编号 - P55085
UniProt汇总 FUNCTION: SwissProt: P55085 # Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone.
SIZE: 397 amino acids; 44126 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
SIMILARITY: SwissProt: P55085 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,AB2201,Anti-mPER1 (residues 6-21) Antibody
下一件merck millipore产品：merck millipore,默克密理博,05-1000,Anti-Phosphoserine Antibody, clone 4A4 (mouse IgG1)
相关产品
merck millipore,默克密理博,SF-1213,PARK2; Mouse, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,ABT95,Anti-TGN46, Antibody
merck millipore,默克密理博,ABC289,Anti-NPC2 Antibody
merck millipore,默克密理博,AB2201,Anti-mPER1 (residues 6-21) Antibody
merck millipore,默克密理博,05-1000,Anti-Phosphoserine Antibody, clone 4A4 (mouse IgG1)
merck millipore,默克密理博,ECM510,QCM Chemotaxis Cell Migration Assay, 96-well (8 µm), fluorimetric
merck millipore,默克密理博,HTS060M,ChemiScreen™ Human V2 Vasopressin Receptor Membrane Preparation
merck millipore,默克密理博,SLVV033RS,Millex-VV，0.1 µm，PVDF，33 mm，可 γ 射线灭菌，已灭菌