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品种反应性 主要应用 宿主 格式 抗体类型 A ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB4073 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Farnesyl Antibody 背景信息 Protein isoprenylation is a post-translational modification that affects about 0.5% of cellular proteins and is essential for the biological activity of proteins. Two enzymes catalyze theattachment of two prenyl groups to the sulfhydryl group of carboxyl-terminal cysteine groups. Proteins which are prenylated by these enzymes have a distinct motif at the C-terminal of the protein, C-A1-A2-X (C = Cysteine, A 1 & A2 = aliphatic amino acids). The two enzymes involved in this transfer are farnesyltransferase and geranylgeranyltransferase. These transfer a 15 carbon farnesyl or a 20 carbon geranygeranyl, respectively, from aprenyl-pyrophosphate to the protein. Examples of proteins containing this C-A-A-X motif are members of the Ras small G protein family, the nuclear lamins and the gamma subunit oftrimeric G proteins. Prenylation of proteins is necessary for membrane association of proteins as well as protein-protein interactions and the nature of the linked isoprenyl group can influence the protein interactions, such as the interaction between G proteins and receptors. 产品信息 格式 Purified 演示 Purified immunoglobulin. Sterile liquid in phosphate buffered saline and 0.08% sodium azide. 应用 应用 Anti-Farnesyl Antibody detects level of Farnesyl & has been published & validated for use in ELISA & IF. 主要应用 - ELISA
应用说明 ELISA
Immunofluoresecence
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Antibody developed using farnesyl cysteine conjugated to KLH. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes farnesyl motif derived from isoprenylated C-A-A-X sequence. Also cross-reacts with geranylgeranyl motif. Detects KLH as well. 品种反应性 All 抗体类型 Polyclonal Antibody 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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