merck millipore,默克密理博,AB3092,Anti-Orexin-1 Receptor Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB, ELISA	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB3092
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Orexin-1 Receptor Antibody
Alternate Names	Hypocretin Receptor 1 OX1R
背景信息	Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R.

产品信息
格式	Affinity Purified
控制	Hypothalamus
演示	Affinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA.

应用
应用	This Anti-Orexin-1 Receptor Antibody is validated for use in ELISA, WB for the detection of Orexin-1 Receptor.
主要应用	Western Blotting ELISA
应用说明	Western blot: 1-10 μg/mL using Chemiluminescence technique. Protein runs at 45-48 kDa. ELISA: 1:10,000 -1:100,000 against 50-100 ng/wel immunogen peptide. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	A 16 aa peptide near the N-terminus of rat OX1R and a 16 aa peptide near the C-terminus of human OX1R.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Recognizes Rat and Human Orexin-1.
品种反应性	RatHumanMouse
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_001525.1
Entrez基因汇总	HCRTR1, or orexin 1 receptor (OX1R), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. HCRTR1 selectively binds the orexin A neuropeptide. It shares 64% identity with HCRTR2.
基因符号	OX1R HCRTR1 Ox1r
纯化方法	Immunoaffinity purified
UniProt编号	O43613
UniProt汇总	FUNCTION: SwissProt: O43613 # Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). SIZE: 425 amino acids; 47522 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: O43613 ## Belongs to the G-protein coupled receptor 1 family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

包装信息
数量	50 µg

merck millipore,默克密理博,AB3092,Anti-Orexin-1 Receptor Antibody

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