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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB2235 描述 Anti-Taurine Transporter Antibody Alternate Names - solute carrier family 6 (neurotransmitter transporter, taurine), member 6
- solute carrier family 6 (neurotransmitter transporter
- taurine)
背景信息 Taurine (2-aminoethane sulfonic acid), a beta-amino acid with a negatively charged sulfonic group is one of the most abundant amino acid in the brain. It is particularly enriched in excitable tissues, particularly those that generate oxidants. Taurine is produced by cysteine metabolism and obtained from diet as well. It is chemically inert molecule with a long turnover rate. It is not incorporated into proteins. It is thought to pay a major role in osmoregulation. It is also postulated to play a critical role in neurotransmission, neuromodulation, and membrane stabilization, neuronal differentiation, migration, synaptogenesis, and development. Taurine is transported to various target tissues by Na-dependent high affinity uptake system carried out in two distinct membrane transporter proteins: a high affinity (Km 40 uM) taurine transporter (TAU-1 or TAUT-1) and a beta-alanine and taurine transporter protein (Km 4.5 uM) known as TAUT-2 . Both TAUT-1/2 share significant sequence homology with the GABA and Glycine transporters that are characterized by the presence of 12 transmembrane domains. Taurine transporters are found in brain, retina and many other tissues. 产品信息 格式 Purified 控制 - Rat P1 brain.
演示 Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3 应用 应用 This Anti-Taurine Transporter Antibody is validated for use in WB for the detection of Taurine Transporter. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic Linear Peptide. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Cat. AB2235 recognizes Taurine Transporter. 品种反应性 Rat Species Reactivity Note Rat. May react with mouse based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001134367.1
基因符号 - TAUT 1
- MGC10619
- MGC131729
UniProt编号 - P31643
UniProt汇总 FUNCTION: Required for the uptake of taurine.
LOCATION: Membrane; Multi-pass membrane protein.
SPECIFICITY: Brain and peripheral tissues.
PTM: Down-regulated upon Ser-322 phosphorylation (By similarity).
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family.产品使用声明 质量保证 Routinely tested on western blot.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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