merck millipore,默克密理愽
  • merck millipore,默克密理博,AB2231,Anti-Dopamine Transporter; 100 µg Antibody

  • merck millipore,默克密理博,AB2231,Anti-Dopamine Transporter; 100 µg Antibody

    产品名称：Anti-Dopamine Transporter; 100 µg Antibody
    产品型号：AB2231
    This Anti-Dopamine Transporter, 100 µg Antibody is validated for use in WB for the detection of Dopamine Transporter, 100 µg.

    merck millipore,默克密理博,AB2231,Anti-Dopamine Transporter; 100 µg Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB2231,Anti-Dopamine Transporter; 100 µg Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB2231
    描述 Anti-Dopamine Transporter; 100 µg Antibody
    Alternate Names
    • variable number tandem repeat (VNTR)
    • DA transporter
    • dopamine transporter
    • solute carrier family 6 (neurotransmitter transporter, dopamine),member 3
    • dopamine),member 3
    背景信息 Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT), a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. DAT is also the target of several “DAT-blockers” including amphetamines and cocaine. These chemicals inhibit the action of DAT and, to a lesser extent, the other monoamine transporters, but their effects are mediated by separate mechanisms.
    产品信息
    格式 Purified
    控制
    • Rat Brain Lysate.
    演示 Purified Antibody in PBS with 0.1% NaN3
    应用
    应用 This Anti-Dopamine Transporter, 100 µg Antibody is validated for use in WB for the detection of Dopamine Transporter, 100 µg.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic Linear Peptide
    表位 N-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Cat. AB2231 recognizes the N-terminus of the reduced and non reduced forms of DAT.
    品种反应性 RatMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001044.3
    Entrez基因汇总 The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. The DAT1 gene has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse (Vandenbergh et al., 1992 [PubMed 1359373]).[supplied by OMIM]
    基因符号
    • DAT 1
    • DAT
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q01959
    UniProt汇总 FUNCTION: Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
    SUBUNIT: Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
    SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family.
    产品使用声明
    质量保证 Routinelyevaluated by western blot on rat brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB2231,Anti-Dopamine Transporter; 100 µg Antibody

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