merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1962,Anti-Paxillin Antibody, phospho-specific [Ser178]

  • merck millipore,默克密理博,AB1962,Anti-Paxillin Antibody, phospho-specific [Ser178]

    产品名称：Anti-Paxillin Antibody, phospho-specific [Ser178]
    产品型号：AB1962
    This Anti-Paxillin Antibody, phospho-specific [Ser178] is validated for use in ELISA, WB for the detection of Paxillin.

    merck millipore,默克密理博,AB1962,Anti-Paxillin Antibody, phospho-specific [Ser178]

  • 产品介绍
  • merck millipore,默克密理博,AB1962,Anti-Paxillin Antibody, phospho-specific [Ser178]

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1962
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Paxillin Antibody, phospho-specific [Ser178]
    背景信息 Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells. Thus, phosphorylation paxillin at serine 178 may be important during cell migration.
    产品信息
    格式 Affinity Purified
    演示 Affinity-purified antibody is supplied in 100 μl phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
    应用
    应用 This Anti-Paxillin Antibody, phospho-specific [Ser178] is validated for use in ELISA, WB for the detection of Paxillin.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1:500 ELISA: 1:2000
    生物信息
    免疫原品种 Synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 178 of human paxillin. This human sequence is highly conserved in rat and mouse paxillin.
    表位 phosphoserine 178
    宿主 Rabbit
    特异性 This antibody detects a 68 kDa protein corresponding to the molecular weight of phosphorylated paxillin on SDS-PAGE immunoblots of EGF treated A431 cells, but not in A431 control cells. Similar results were seen in calyculin A treated human A431 and aortic endothelial cells.
    同种型 IgG
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002859.1
    基因符号
    • PXN
    • Paxillin.
    • paxillin
    • FLJ16691
    修改
    • Phosphorylation
    UniProt编号
    • P49023
    UniProt汇总 FUNCTION: SwissProt: P49023 # Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
    SIZE: 591 amino acids; 64533 Da
    SUBUNIT: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
    PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
    SIMILARITY: SwissProt: P49023 ## Belongs to the paxillin family. & Contains 4 LIM zinc-binding domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C for one year from date of receipt. Do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1962,Anti-Paxillin Antibody, phospho-specific [Ser178]

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