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merck millipore,默克密理博,AB1868P,Anti-Stromal Cell-Derived Factor-1α Antibody
产品名称：Anti-Stromal Cell-Derived Factor-1α Antibody
产品型号：AB1868P
Detect Stromal Cell-Derived Factor-1α using this Anti-Stromal Cell-Derived Factor-1α Antibody validated for use in ELISA, WB, NEUT.
merck millipore,默克密理博,AB1868P,Anti-Stromal Cell-Derived Factor-1α Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1868P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Stromal Cell-Derived Factor-1α Antibody Alternate Names - SDF-1alpha
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Lyophilized from 0.5X PBS pH 7.2. Reconstitute with sterile distilled water. 应用 应用 Detect Stromal Cell-Derived Factor-1α using this Anti-Stromal Cell-Derived Factor-1α Antibody validated for use in ELISA, WB, NEUT. 主要应用 - Western Blotting
- ELISA
应用说明 ELISA: 0.5 μg/mL this dilution will allow detection (in direct ELISA) of 0.2-0.4 ng/well when human SDF-1alpha is used to coat the plate.
Western blot: 0.1-0.2 μg/mL, this dilution should offer a detection limit of 1.5-3.0 ng/lane, under reducing or non-reducing conditions.
Optimal working dilutions must be determined by the end user.
Neutralization: To yield one-half maximal inhibition (ND50) of the biological activity of human SDF-1alpha (100 ng/mL), a concentration of 2.0-0.4 ng/well of recombinant human SDF-1alpha生物信息 免疫原品种 Highly pure (>98%) recombinant human SDF-1alpha. 宿主 Rabbit 特异性 Reacts with human SCDF-1alpha 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_199168.2
- NM_000609.4
- NM_001033886.1
Entrez基因汇总 For background information on chemokines, see CXCL11 (SCYB11; MIM 604852). Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF (see MIM 191160), or IL1 (see MIM 147760). The intercrines are characterized by the presence of 4 conserved cysteines which form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, which includes beta chemokine, the cysteine residues are adjacent to each other. In the CXC subfamily, which includes alpha chemokine, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group.[supplied by OMIM] 基因符号 - SDF-1a
- CXCL12
- SDF1A
- TPAR1
- TLSF
- SDF-1
- SDF1
- SDF1B
- SCYB12
- hIRH
- TLSF-b
- SDF-1b
- PBSF
- TLSF-a
UniProt编号 - P48061
UniProt汇总 FUNCTION: SwissProt: P48061 # Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.
SIZE: 93 amino acids; 10666 Da
SUBCELLULAR LOCATION: Secreted.
PTM: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
SIMILARITY: SwissProt: P48061 ## Belongs to the intercrine alpha (chemokine CxC) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile water to a concentration of =0.2 mg/ml the antibody is stable for at least six weeks at 2-4°C. 包装信息 数量 50 µg
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