merck millipore,默克密理愽
  • merck millipore,默克密理博,14-597,Histone H2A.Z Protein, human recombinant, 100 µg

  • merck millipore,默克密理博,14-597,Histone H2A.Z Protein, human recombinant, 100 µg

    产品名称：Histone H2A.Z Protein, human recombinant, 100 µg
    产品型号：14-597
    Recombinant human histone H2A.Z, produced in E. coli, purified by ion exchange chromotography. For use in Kinase Assays.

    merck millipore,默克密理博,14-597,Histone H2A.Z Protein, human recombinant, 100 µg

  • 产品介绍
  • merck millipore,默克密理博,14-597,Histone H2A.Z Protein, human recombinant, 100 µg

    重要规格表

    主要应用 Entrez基因编号 Uni Prot编号
    KANM_002106.3P0C0S5
    描述
    产品目录编号 14-597
    品牌系列 Upstate
    商名
    • Upstate
    描述 Histone H2A.Z Protein, human recombinant, 100 µg
    概述 Recombinant human histone H2A.Z
    应用
    应用 Recombinant human histone H2A.Z, produced in E. coli, purified by ion exchange chromotography. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 produced in E. coli
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002106.3
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
    基因符号
    • H2A.z
    • H2AFZ
    • H2A/z
    • H2A.Z
    • MGC117173
    • H2AZ
    纯化方法 Ion exchange chromatography
    UniProt编号
    • P0C0S5
    UniProt汇总 FUNCTION: SwissProt: P0C0S5 # Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
    SIZE: 128 amino acids; 13553 Da
    SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP (By similarity).
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. & Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity). & Not phosphorylated (By similarity).
    SIMILARITY: SwissProt: P0C0S5 ## Belongs to the histone H2A family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at 4°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,14-597,Histone H2A.Z Protein, human recombinant, 100 µg

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