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merck millipore,默克密理博,AB1765P,Anti-Dopamine D1A Receptor Antibody, CT, cytoplasmic
产品名称：Anti-Dopamine D1A Receptor Antibody, CT, cytoplasmic
产品型号：AB1765P
Anti-Dopamine D1A Receptor Antibody, C-terminus, cytoplasmic is an antibody against Dopamine D1A Receptor for use in ELISA, IH & WB.
merck millipore,默克密理博,AB1765P,Anti-Dopamine D1A Receptor Antibody, CT, cytoplasmic
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, Po WB, ELISA, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB1765P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Dopamine D1A Receptor Antibody, CT, cytoplasmic 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 100mM Tris, pH 7.5 with 0.2% BSA and 0.05% sodium azide. 应用 应用 Anti-Dopamine D1A Receptor Antibody, C-terminus, cytoplasmic is an antibody against Dopamine D1A Receptor for use in ELISA, IH & WB. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Western blot: 1-10 μg/mL (Chemiluminescence technique). An antibody made to this peptide has been shown to detect 2 proteins of 50 and 75 kDa in solubilized hippocampal membranes. The 75 kDa band was not visible in striatum (Huang et al. 1992; O'Connel et al. 1995). Approximately 100-400 μg of protein/lane should be loaded to visualize the 75 kDa band (Huang et al. 1992; O'Connel et al. 1995) that is present in relatively small amounts.
Immunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed sections.
ELISA: 0.5-1.0 μg/mL (1 μg/mL D1A peptide (Cat. Number AG259)/well)
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 A 13 amino acid peptide sequence (amino acids 403-415) from rat D1A (Monsma et al. 1990; Zhou et al. 1990; Zhou et al. 1992; O'Dowd et al. 1990). This peptide is predicted to be cytoplasmic. 表位 C-terminus, cytoplasmic 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Dopamine Receptor D1A. An antibody made to the D1R peptide has been shown to detect 2 proteins of 50 and 75 kDa in solubilized hippocampal membranes by Western blot. The 75 kDa band was not visible in striatum (Huang et al. 1992). Approximately 100-400 μg of protein/lane should be loaded to visualize the 75 kDa band. By immunohistochemistry D1R has been localized in various regions of the rat brain (Huang et al. 1992).
May recognize porcine or bovine (100 % similarity) or human (78% similarity).品种反应性 RatPig 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000794.3
Entrez基因汇总 This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. 基因符号 - D
- DRD1
- DRD1A
- DADR
UniProt编号 - P21728
UniProt汇总 FUNCTION: SwissProt: P21728 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
SIZE: 446 amino acids; 49293 Da
SUBUNIT: Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (By similarity).
TISSUE SPECIFICITY: Detected in caudate, nucleus accumbens and in the olfactory tubercle.
SIMILARITY: SwissProt: P21728 ## Belongs to the G-protein coupled receptor 1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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