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merck millipore,默克密理博,05-720,Anti-ING1 Antibody, clone CAb3
产品名称：Anti-ING1 Antibody, clone CAb3
产品型号：05-720
Anti-ING1 Antibody, clone CAb3 is a high quality Mouse Monoclonal Antibody for the detection of ING1 & has been validated in IP, WB, ICC.
merck millipore,默克密理博,05-720,Anti-ING1 Antibody, clone CAb3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-720 品牌系列 Upstate
商名 - Upstate
描述 Anti-ING1 Antibody, clone CAb3 产品信息 格式 Purified 演示 PBS, pH 7.4 and 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-ING1 Antibody, clone CAb3 is a high quality Mouse Monoclonal Antibody for the detection of ING1 & has been validated in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 fusion protein corresponding to residues 70-279 of human ING1b 克隆 clone CAb3 宿主 Mouse 特异性 ING1a, ING1b and ING1c 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005537
Entrez基因汇总 This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. 基因符号 - p24ING1c
- ING1
- p47ING1a
- p33ING1b
- p33ING1
- p33
- p47
纯化方法 Protein G chromatography UniProt编号 - Q9UK53
UniProt汇总 FUNCTION: SwissProt: Q9UK53 # Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
SIZE: 422 amino acids; 46781 Da
SUBUNIT: Interacts with TP53.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
DISEASE:SwissProt: Q9UK53 # Defects in ING1 are a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].
SIMILARITY: SwissProt: Q9UK53 ## Belongs to the ING family. & Contains 1 PHD-type zinc finger.产品使用声明 质量保证 routinely evaluated by immunoblot on nuclear extracts from human brain tumor SNB19 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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