- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, B WB, ELISA, IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB176 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Adenosine Deaminase Antibody Alternate Names - EC 5.4.3.3)
- Adenosine Aminohydrolase
产品信息 格式 Serum 演示 Rabbit antiserum. 应用 应用 This Anti-Adenosine Deaminase Antibody is validated for use in ELISA, IH, WB for the detection of Adenosine Deaminase. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Immunohistochemistry - 1:250 (Fixative 4.0% paraformaldehyde).
ELISA - 1:3,000.
Western Blot - 1:2,500 (41 kDa).
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Calf Spleen Adenosine Deaminase. Due to high sequence identity, the antiserum is expected to react with adenosine deaminase from most mammalian species. 宿主 Rabbit 特异性 Adenosine Deaminase. 品种反应性 RatBovine 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000022.2
Entrez基因汇总 This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. 基因符号 - EC 3.5.4.4
- ADA
UniProt编号 - P00813
UniProt汇总 SIZE: 363 amino acids; 40764 Da
TISSUE SPECIFICITY: Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.
DISEASE: SwissProt: P00813 # Defects in ADA are a cause of autosomal recessive severe combined immuno-deficiency (SCID) [MIM:102700]. SCID is a congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Onset is during infancy. Less often, immune dysfunction develops later in childhood (delayed) and in a few cases ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity, mainly in African descent, who have partial ADA deficiency. Most patients are compound heterozygotes. SCID arises if both mutations eliminate ADA activity, whereas a single allele with residual activity can confer a milder phenotype. ADA deficiency accounts for about one-half of cases of autosomal recessive SCID. & In hereditary hemolytic anemia, the level of this enzyme in erythrocytes increases 50-70 times.
SIMILARITY: SwissProt: P00813 ## Belongs to the adenosine and AMP deaminases family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C for up to 6 months or -70°C for up to 12 months in undiluted aliquots. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,04-1047,Anti-EZH 1/2 Antibody, clone EP1408Y, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,07-565,Anti-Necdin Antibody
相关产品
merck millipore,默克密理博,05-321X,Anti-Phosphotyrosine Antibody, clone 4G10
merck millipore,默克密理博,SLGP05010,Millex-GP，0.22 µm，改良聚醚砜，50 mm，HB/HB，射线灭菌
merck millipore,默克密理博,07-1614,Anti-XRCC2 Antibody
merck millipore,默克密理博,04-1047,Anti-EZH 1/2 Antibody, clone EP1408Y, rabbit monoclonal
merck millipore,默克密理博,07-565,Anti-Necdin Antibody
merck millipore,默克密理博,71530,T7 Tail Fiber Monoclonal Antibody
merck millipore,默克密理博,373260,Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem
merck millipore,默克密理博,DP02A,Anti-SV40 T Antigen (Ab-2) Mouse mAb (PAb416) Agarose Conjugate