- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,07-1614,Anti-XRCC2 Antibody
产品名称：Anti-XRCC2 Antibody
产品型号：07-1614
Use Anti-XRCC2 Antibody (rabbit polyclonal antibody) validated in IHC(P), WB, ICC to detect XRCC2 also known as DNA repair protein XRCC2, X-ray repair complementing defective repair in Chinese hamster More>>
merck millipore,默克密理博,07-1614,Anti-XRCC2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1614 Replaces MABE556 描述 Anti-XRCC2 Antibody Alternate Names - X-ray repair, complementing defective, repair in Chinese hamster
- DNA repair protein XRCC2
- X-ray repair complementing defective repair in Chinese hamster cells 2
- X-ray repair cross complementing protein 2
- X-ray repair cross-complementing protein 2
- X-ray repair
- complementing defective
背景信息 X-ray repair cross-complementing protein (XRCC2) is a member of the RecA family which is essential for DNA repair and maintenance. XRCC2 also belongs to the Rad51 subfamily of proteins involved in double stranded DNA break repair. XRCC2 is thought to encode a member of the RecA/Rad51 related protein family which maintains chromosome stability and repairs DNA damage. XRCC2 and RAD51 interact to form a multimeric ring in the absence of DNA. XRCC2 is thought to load Rad51 onto gapped DNA. 产品信息 格式 Affinity Purified 控制 - Jurkat cell lysate, human lung, NIH/3T3, A431, HeLa cells.
演示 Rabbit polyclonal precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives 应用 应用 Use Anti-XRCC2 Antibody (rabbit polyclonal antibody) validated in IHC(P), WB, ICC to detect XRCC2 also known as DNA repair protein XRCC2, X-ray repair complementing defective repair in Chinese hamster cells 2. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry:
Anti-XRCC2 polyclonal was used in immunocytochemistry to positively stain the nucleus on A431, NIH/3T3 and HeLa cells.
Immunohistochemistry(paraffin): Anti-XRCC2 antibody was used for immunohistochemistry on human lung tissue.
Formalin-fixed and paraffin-embedded Human lung tissue stained with anti-XRCC2 (1:100) with Citrate pH 6.0 (HIER).
生物信息 免疫原品种 A synthetic peptide corresponding to amino acids 206-217 of XRCC2. 宿主 Rabbit 特异性 This antibody recognizes XRCC2. 品种反应性 MouseHuman Species Reactivity Note Tested on human and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005431
Entrez基因汇总 This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq].
基因符号 - RAD51-like
- DKFZp781P0919
纯化方法 Affinity purified polyclonal precipitated in ammonium sulfate. UniProt编号 - O43543
UniProt汇总 FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Ref.6
SUBUNIT STRUCTURE: Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.10
SIMILARITY: Belongs to the recA family. RAD51 subfamily.
产品使用声明 质量保证 Western Blot Analysis:
1:500 dilution of this antibody detected XRCC2 in 10 µg of a Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,SLGP05010,Millex-GP，0.22 µm，改良聚醚砜，50 mm，HB/HB，射线灭菌
下一件merck millipore产品：merck millipore,默克密理博,345815,Gentamycin Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested - CAS 1405-41-0 - Calbiochem
相关产品
merck millipore,默克密理博,119107,ATP Assay Kit
merck millipore,默克密理博,MABC202,Anti-APC Antibody, clone FE9
merck millipore,默克密理博,MAB5360,Anti-Spinocerebellar Ataxia Type 3 Antibody, clone 1H9
merck millipore,默克密理博,05-321X,Anti-Phosphotyrosine Antibody, clone 4G10
merck millipore,默克密理博,SLGP05010,Millex-GP，0.22 µm，改良聚醚砜，50 mm，HB/HB，射线灭菌
merck millipore,默克密理博,04-1047,Anti-EZH 1/2 Antibody, clone EP1408Y, rabbit monoclonal
merck millipore,默克密理博,AB176,Anti-Adenosine Deaminase Antibody
merck millipore,默克密理博,07-565,Anti-Necdin Antibody
merck millipore,默克密理博,71530,T7 Tail Fiber Monoclonal Antibody