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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB15852 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-HTRA1 Serine peptidase Antibody 背景信息 The defining features of the widely conserved HtrA (high temperature requirement) family of serine proteases are the combination of a catalytic protease domain with one or more C-terminal PDZ domains and reversible zymogen activation. Even though HtrAs have previously been implicated in protein quality control and various diseases, including cancer, arthritis, and neuromuscular disorder, the biology of the human family members is not well understood. New studies suggest that HtrA1 is directly involved in the amyloid pathway as it degrades various fragments of amyloid precursor protein while an HtrA1 inhibitor causes accumulation of amyloid beta in astrocyte cell culture supernatants. Furthermore, HtrA1 colocalizes with amyloid deposits in human brain samples. 产品信息 格式 Purified 演示 Liquid in PBS with 0.1% sodium azide. 应用 应用 Anti-HTRA1 Serine peptidase Antibody is an antibody against HTRA1 Serine peptidase for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide from human HTRA1 Serine peptidase. 宿主 Rabbit 特异性 HTRA1 Serine peptidase. By Western blot the antibody reacts with a band at ~ 50 kDa on human heart lysate. An additional band at ~240 kDa may also be seen depending on sample and antibody concentration used. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002775.3
Entrez基因汇总 This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. 基因符号 - EC 3.4.21.-
- HTRA1
- IGFBP5-protease
- HtrA
- HTRA
- PRSS11
- ARMD7
- ORF480
- L56
纯化方法 Protein A purfied UniProt编号 - Q92743
UniProt汇总 FUNCTION: SwissProt: Q92743 # Protease that regulate the availability of IGFs by cleaving IGF-binding proteins.
SIZE: 480 amino acids; 51287 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in a variety of tissues, with strongest expression in placenta.
DISEASE: SwissProt: Q92743 # Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.
SIMILARITY: SwissProt: Q92743 ## Belongs to the peptidase S1B family. & Contains 1 IGFBP N-terminal domain. & Contains 1 Kazal-like domain. & Contains 1 PDZ (DHR) domain.储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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