merck millipore,默克密理博,AB1553,Anti-Metabotropic Glutamate Receptor 2/3 Antibody

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merck millipore,默克密理博,AB1553,Anti-Metabotropic Glutamate Receptor 2/3 Antibody
产品名称：Anti-Metabotropic Glutamate Receptor 2/3 Antibody
产品型号：AB1553
Anti-Metabotropic Glutamate Receptor 2/3 Antibody detects level of Metabotropic Glutamate Receptor 2/3 & has been published & validated for use in IH(P), IH & WB.

merck millipore,默克密理博,AB1553,Anti-Metabotropic Glutamate Receptor 2/3 Antibody

产品介绍

merck millipore,默克密理博,AB1553,Anti-Metabotropic Glutamate Receptor 2/3 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, Mk	WB, IHC	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB1553
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Metabotropic Glutamate Receptor 2/3 Antibody
Alternate Names	mGluR2/3

产品信息
格式	Affinity Purified
演示	Affinity purified using the immunogen peptide. Lyophilized from PBS containing 1% BSA.

应用
应用	Anti-Metabotropic Glutamate Receptor 2/3 Antibody detects level of Metabotropic Glutamate Receptor 2/3 & has been published & validated for use in IH(P), IH & WB.
主要应用	Western Blotting Immunohistochemistry
应用说明	Western blot analysis can be done at final concentrations of 0.1-0.5 μg/mL. AB1553 can be used for immunocytochemistry using paraformaldehyde or paraformaldehyde/glutaraldehyde fixed tissue with light and electron microscopy. Cryostat and vibratome sections can be used with or without Triton X-100 treatment. Final concentrations recommended are 0.1-0.5 μg/mL. The antibody has not been tested for use in immunoprecipitation. However, antibodies to the carboxy termini of other glutamate receptors are very effective in immunoprecipitation. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Carboxy terminus peptide of rat mGluR2 conjugated to BSA with glutaraldehyde (NGREVVDSTTSSL).
宿主	Rabbit
特异性	Metabotropic glutamate receptors mGluR2 and mGluR3, which have nearly identical C-termini. There is also a very slight recognition of mGluR5. Western blot analysis of rat brain shows bands migrating at Mr = 100,000 (which contains both mGluR2 and mGluR3) and 190,000. The larger band is thought to be a dimer of the smaller band.
品种反应性	RatMonkey
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_000839.2
Entrez基因汇总	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
基因符号	GLUR2 GRM2 mGlu2 GPRC1B MGLUR2 mGluR2
UniProt编号	Q14416
UniProt汇总	FUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. SIZE: 872 amino acids; 95568 Da SUBUNIT: Interacts with GRASP (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain. SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain lyophilized material at 2-8°C or -20°C. Reconstitute to 500 μL with sterile distilled water. Store reconstituted material frozen (-20°C or -80°C) in undiluted aliquots for up to six months. Avoid repeated thawing and refreezing. Diluted antibody containing 0.1% sodium azide for Western blot analysis can be stored for several weeks and reused repeatedly.

包装信息
数量	50 µg

merck millipore,默克密理博,AB1553,Anti-Metabotropic Glutamate Receptor 2/3 Antibody

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