merck millipore,默克密理博,07-824,Anti-phospho-eIF4G (Ser1108) Antibody

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merck millipore,默克密理博,07-824,Anti-phospho-eIF4G (Ser1108) Antibody
产品名称：Anti-phospho-eIF4G (Ser1108) Antibody
产品型号：07-824
This Anti-phospho-eIF4G (Ser1108) Antibody is validated for use in WB for the detection of phospho-eIF4G (Ser1108).

merck millipore,默克密理博,07-824,Anti-phospho-eIF4G (Ser1108) Antibody

产品介绍

merck millipore,默克密理博,07-824,Anti-phospho-eIF4G (Ser1108) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-824
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-eIF4G (Ser1108) Antibody
Alternate Names	eukaryotic translation initiation factor 4 gamma, EIF4F eukaryotic translation initiation factor 4 gamma

产品信息
格式	Affinity Purified

应用
应用	This Anti-phospho-eIF4G (Ser1108) Antibody is validated for use in WB for the detection of phospho-eIF4G (Ser1108).
主要应用	Western Blotting

生物信息
免疫原品种	KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser1108 of human eIF4G.
宿主	Rabbit
特异性	Recognizes eIF4G phosphorylated on Ser1108.
同种型	IgG
品种反应性	Human
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_198244.1 NM_004953.3 NM_182917.2 NM_198241.1 NM_198242.1
Entrez基因汇总	The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.
基因符号	DKFZp686A1451 EIF4G1 EIF4GI EIF4G eIF-4G1 EIF4-gamma EIF4F p220
修改	Phosphorylation
纯化方法	Immunoaffinity purified
UniProt编号	Q04637
UniProt汇总	FUNCTION: SwissProt: Q04637 # Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. SIZE: 1600 amino acids; 175535 Da SUBUNIT: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. During rotaviral infection, rotavirus RNA-binding protein NSP3 interacts with EIF4G1 and takes the place of PABPC1. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. PTM: Phosphorylated at multiple sites in vivo. & Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. SIMILARITY: SwissProt: Q04637 ## Belongs to the eIF4G family. & Contains 1 MA3 domain. & Contains 1 MIF4G domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

包装信息
数量	100 µL

merck millipore,默克密理博,07-824,Anti-phospho-eIF4G (Ser1108) Antibody

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