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merck millipore,默克密理博,AB1255,Anti-Cytochrome P450 Enzyme CYP1A1 and CYP1A2 Antibody
产品名称：Anti-Cytochrome P450 Enzyme CYP1A1 and CYP1A2 Antibody
产品型号：AB1255
Detect Cytochrome P450 Enzyme CYP1A1 & CYP1A2 using this Anti-Cytochrome P450 Enzyme CYP1A1 & CYP1A2 Antibody validated for use in ELISA & WB.
merck millipore,默克密理博,AB1255,Anti-Cytochrome P450 Enzyme CYP1A1 and CYP1A2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB, ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1255 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytochrome P450 Enzyme CYP1A1 and CYP1A2 Antibody 产品信息 格式 Serum 控制 - POSITIVE CONTROL: rat hepatic microsomal fraction.
演示 Rabbit antiserum. Liquid. Contains no preservative. 应用 应用 Detect Cytochrome P450 Enzyme CYP1A1 & CYP1A2 using this Anti-Cytochrome P450 Enzyme CYP1A1 & CYP1A2 Antibody validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: useful for the simultaneous detection of rat CYP1A1 (57 kDa) and CYP1A2 (54 kDa), which can be separated electrophoretically.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide 宿主 Rabbit 特异性 Reacts with rat cytochrome P450 enzyme CYP1A1 and CYP1A2 on Western blots of hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000499.2
Entrez基因汇总 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. 基因符号 - AHH
- CYP1A1
- CP11
- P1-450
- CYPIA1
- P450-C
- CYP1
- P450DX
- P450-P1
- AHRR
UniProt编号 - P05177
- P04798
UniProt汇总 FUNCTION: SwissProt: P05177 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen.
SIZE: 515 amino acids; 58294 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Liver.
SIMILARITY: SwissProt: P05177 ## Belongs to the cytochrome P450 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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