merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1254,Anti-Cytochrome P450 Enzyme CYP3A4 Antibody

  • merck millipore,默克密理博,AB1254,Anti-Cytochrome P450 Enzyme CYP3A4 Antibody

    产品名称：Anti-Cytochrome P450 Enzyme CYP3A4 Antibody
    产品型号：AB1254
    Anti-Cytochrome P450 Enzyme CYP3A4 Antibody detects level of Cytochrome P450 Enzyme CYP3A4 & has been published & validated for use in IH & WB.

    merck millipore,默克密理博,AB1254,Anti-Cytochrome P450 Enzyme CYP3A4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB1254,Anti-Cytochrome P450 Enzyme CYP3A4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Po, HWB, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB1254
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cytochrome P450 Enzyme CYP3A4 Antibody
    产品信息
    格式 Serum
    控制
    • Liver tissue
    演示 Rabbit antiSerum. Liquid containing no preservative.
    应用
    应用 Anti-Cytochrome P450 Enzyme CYP3A4 Antibody detects level of Cytochrome P450 Enzyme CYP3A4 & has been published & validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western blot: 1:1000-1:2000: Using microsomal membrane fractions, detects a band at ~54kDa; other bands may be present as well. Antibody has been successfully used to detect CYP3A4 on LICOR fluorescent westerns as well.

    Immunohistochemistry: 10% formalin fixed, paraffin embedded tissues 1:200-1:400, microwave-citric acid antigen recovery is suggested.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 A synthetic peptide containing the C-terminal sequence of TVSGA from human CYP3A4. The peptide was coupled to KLH.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The rabbit polyclonal serum detects CYP3A4 in humans and rats; by sequence homology of the immunogen used, cross reactivity to CYP3A7, 3A6v4;3A2v1, 3A8, 3A9 may be expected but is untested at this time.
    品种反应性 PigHuman
    Species Reactivity Note Expects reactivity with rat and other mammals based on homology, but this is untested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_017460.3
    Entrez基因汇总 This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.
    基因符号
    • EC 1.14.13.97
    • CYP3A4
    • CYPIIIA3
    • P450-PCN1
    • P450C3
    • P450PCN1
    • MGC126680
    • HLp
    • CYP3A
    • CP34
    • CYPIIIA4
    • CP33
    • NF-25
    • HLP
    • CYP3A3
    • EC 1.14.13.67
    纯化方法 Unpurified
    UniProt编号
    • P08684
    UniProt汇总 FUNCTION: SwissProt: P08684 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
    SIZE: 503 amino acids; 57343 Da
    SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
    TISSUE SPECIFICITY: Expressed in prostate and liver.
    SIMILARITY: SwissProt: P08684 ## Belongs to the cytochrome P450 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1254,Anti-Cytochrome P450 Enzyme CYP3A4 Antibody

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