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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10911 Replaces MABD182 描述 Anti-Osteocalcin Antibody Alternate Names - bone gamma-carboxyglutamate (gla) protein (osteocalcin)
- Bone Gla protein
- Gamma-carboxyglutamic acid-containing protein
背景信息 Osteocalcin belongs to the osteocalcin/matrix Gla protein family. It constitutes 1 to 2% of the total bone protein. It is made by osteoblasts, and is a major component of the noncollagenous bone matrix. It has a high affinity for calcium and binds strongly to apatite. Sixty to ninety percent of de novo synthesized osteocalcin is incorporated into the bone matrix where it binds to hydroxyapatite during matrix mineralization. The remainder of the osteocalcin is released into the circulation where it can be measured as a sensitive marker of bone formation. Osteocalcin found in serum is almost exclusively derived from the bone formation with little or no contribution from the resorption process. Drugs acting primarily on bone resorption, such as bisphosphonates, induce a rapid decline in specific bone resorption markers, whereas osteocalcin levels only change after extended therapy periods, in accordance with the expected dynamics of a bone formation marker. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency. 产品信息 格式 Serum 控制 - Human heart lysate
演示 Serum containing 0.05% sodium azide. 应用 应用 Detect Osteocalcin using this Anti-Osteocalcin Antibody validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to aa 59-74 of osteocalcin protein. 表位 aa 59-74 宿主 Rabbit 特异性 The antibody reacts with the osteocalcin protein. 品种反应性 RatHumanMouse Species Reactivity Note Reacts with human, rat, and mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_199173.3
基因符号 - osteocalcin
- BGP
- OC
- OTTHUMP00000016586
- PMF1
UniProt编号 - P02818
UniProt汇总 FUNCTION: SwissProt: P02818 # Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
SIZE: 100 amino acids; 10963 Da
SUBCELLULAR LOCATION: Secreted.
PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
SIMILARITY: SwissProt: P02818 ## Belongs to the osteocalcin/matrix Gla protein family. & Contains 1 Gla (gamma-carboxy-glutamate) domain产品使用声明 质量保证 Routinely evaluated by Western Blot on human heart lysate.
Western Blot Analysis:
1:500 - 1:5,000 dilution of this antibody detected osteocalcin in 10 μg of human heart lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,MAB810X,Anti-Cytomegalovirus Antibody, clone 8B1.2, Alexa Fluor 488 (ASR)
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