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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10522 Replaces AB9160 描述 Anti-Neuropilin-2 Antibody Alternate Names - vascular endothelial growth factor-165 receptor 2
- Vascular endothelial cell growth factor 165 receptor 2
- neuropilin 2
- receptor for VEGF165 and semaphorins class 3
背景信息 There are two forms of Neuropilin: Neuropilin-1 and Neuropilin-2. These are non–tyrosine kinase receptors that bind to VEGF and semaphorins (SEMA3A, SEMA3B, and SEMA3F) and play an important role in the critical functioning of the nervous system. Neuropilin-2 is expressed in tumor cells, and mature and developing endothelial cells and vascular smooth muscle cells. This expression has been associated with tumor angiogenesis and progression. 产品信息 格式 Serum 控制 - Mouse P1 brain tissue lysate
演示 Unpurified Rabbit Serum containing 0.05% Sodium Azide. 应用 应用 Detect Neuropilin-2 using this Anti-Neuropilin-2 Antibody validated for use in WB, IH, IP & IF. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 His-tagged partial recombinant rat Neuropilin-2 protein. 表位 Unknown 宿主 Rabbit 特异性 This antibody recognizes Neuropilin-2. 同种型 IgG 品种反应性 Mouse Species Reactivity Note Proven to react with mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_110496.1
基因符号 - 1110048P06Rik
- NRP2
- NP2
- NPN2
- PRO2714
- VEGF165R2
- VEGF1265R2
纯化方法 Unpurified UniProt编号 - O35276
UniProt汇总 FUNCTION: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
SUBUNIT STRUCTURE: Heterodimer with NRP1 Probable. Binds PLXNB1 By similarity.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Found in certain neuronal populations of the CNS and in other non-neuronal tissues including mesenchymal tissue lining in the ribs.
DEVELOPMENTAL STAGE: The expression pattern is very dynamic and is developmentally regulated.
SEQUENCE SIMILARITIES: Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse P1 brain tissue lysate.
Western Blot Analysis: 1:1000 dilution of this antibody detected Neuropilin-2 on 10 µg of mouse P1 brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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