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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB10004 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-BARD1 Antibody Alternate Names - BRCA1-associated RING domain protein 1
背景信息 Ring domain E3 ubiquitin ligase. BRCA1 interacts with BARD1 to generate significant ubiquitin ligase activity which catalyzes nontraditional Lys-6-linked polyubiquitin chains in breast cancer. 产品信息 格式 Affinity Purified 演示 Tris-citrate/phosphate buffer, pH 7 to 8 with 0.1% Sodium Azide (NaN3). 应用 应用 Anti-BARD1 Antibody detects level of BARD1 & has been published & validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Immunogen was a synthetic peptide, which represented a portion of human BRCA1 associated Ring domain encoded within exon 4 (LocusLink ID 580). 宿主 Rabbit 特异性 Reacts with BARD1 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000465.1
Entrez基因汇总 This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. 基因符号 - BARD-1
- BARD1
UniProt编号 - Q99728
UniProt汇总 FUNCTION: SwissProt: Q99728 # Implicated in BRCA1-mediated tumor suppression. May, as part of the RNA polymerase-2 holoenzyme, function in the cellular response to DNA damage. In vitro, inhibits pre-mRNA 3' cleavage.
SIZE: 777 amino acids; 86648 Da
SUBUNIT: Homo- and heterodimer. Preferentially forms heterodimers with BRCA1. Can also form heterodimers with CSTF-50.
SUBCELLULAR LOCATION: Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm.
PTM: Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.
DISEASE:SwissProt: Q99728 # Defects in BARD1 gene are found in primary breast, ovarian and uterine cancers.
SIMILARITY: SwissProt: Q99728 ## Contains 3 ANK repeats. & Contains 2 BRCT domains. & Contains 1 RING-type zinc finger.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 - 8°C 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,AP189B,Donkey Anti-Rat IgG Antibody, biotin conjugate, Species Adsorbed
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