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merck millipore,默克密理博,681535,Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
产品名称：Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
产品型号：681535
A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
merck millipore,默克密理博,681535,Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₈H₃₈O₆ 5119-48-2 描述 概述 A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death. 产品目录编号 681535 品牌系列 Calbiochem®
参考 参考 Mohan, R., et al. 2004. Angiogenesis 7, 115.
Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.产品信息 CAS号 5119-48-2 具有ATP竞争性 N 形式 White solid Hill配方 C₂₈H₃₈O₆ 化学配方 C₂₈H₃₈O₆ Molar Mass 470.6 可逆 N 结构配方图像 生物信息 主靶 A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. 主靶IC50 12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation 纯度 ≥94% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH GHS安全信息 RTECS KE7288500 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Carcinogenic / Teratogenic
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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