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merck millipore,默克密理博,676487,VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem
产品名称：VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem
产品型号：676487
The VEGFR2 Kinase Inhibitor III, also referenced under CAS 204005-46-9, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosp More>>
merck millipore,默克密理博,676487,VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₅H₁₄N₂O 204005-46-9 描述 概述 A cell-permeable indolinone compound that acts as a selective, reversible, and ATP-competitive inhibitor of VEGF-R (KDR/Flk-1) and PDGF-R tyrosine kinases (IC50 = 1.04 µM and 20 µM in NIH 3T3 cells overexpressing Flk-1; Km = 530 nM for ATP). Also potently inhibits the proliferation of HUVECs induced by VEGF, bFGF, or ECGS (IC50 = 50 nM, 5.3 µM and 30.5 µM, respectively). Blocks the autophosphorylation of internal tandem duplication (ITD) and wild type Fms-like tyrosine kinase 3 (FLT3) with an IC50 of 0.1 µM. Does not affect the EGF- or FGF- receptor tyrosine kinases activities even at 100 µM concentration. Reported to induce apoptosis and inhibit VEGF-dependent mitogenesis of human endothelial cells. A 10 mM (500 µg/210 µl) solution of VEGF Receptor 2 Kinase Inhibitor III (Cat. No. 676498) in DMSO is also available. 产品目录编号 676487 品牌系列 Calbiochem®
同义词 3-[(2,4-Dimethylpyrrol-5-yl)methylidene]-indolin-2-one, SU5416, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor III, VEGFR Tyrosine Kinase Inhibitor XIV 参考 参考 Tille, J.C., et al. 2003. Exp. Cell Res. 285, 286.
Itokawa, T., et al. 2002. Mol. Cancer Ther. 1, 295.
Ma, J., et al. 2002. J. Pharmacol. Exp. Ther. 305, 833.
Yee, K.W., et al. 2002. Blood 100, 2941.
Mendel, D.B., et al. 2000. Clin. Cancer Res. 6, 4848.
Fong, T.A.T., et al. 1999. Cancer Res. 59, 99.
Sun, L., et al. 1999. J. Med. Chem. 42, 5120.产品信息 CAS号 204005-46-9 具有ATP竞争性 Y 形式 Yellow orange solid Hill配方 C₁₅H₁₄N₂O 化学配方 C₁₅H₁₄N₂O Molar Mass 238.3 可逆 Y 结构配方图像 生物信息 主靶 VEGF-R (KDR/Flk-1) and PDGF-R tyrosine kinases 主靶IC50 1.04 and 20 µM against VEGF-R (KDR/Flk-1) and PDGF-R tyrosine kinases, respectively, in NIH 3T3 cells overexpressing Flk-1; ; Km = 530 nM for ATP 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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