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品种反应性 主要应用 宿主 格式 抗体类型 R, B, H, Ht, M, Po WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-903 品牌系列 Upstate
商名 - Upstate
描述 Anti-PKA Antibody, NT 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol added to 30% 应用 应用 Anti-PKA Antibody, NT detects level of PKA & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide (KKGSEQESVKEFLAK-C) based upon amino acids 8-22 of the human 41kDa alpha isoform of the catalytic subunit of PKA 宿主 Rabbit 特异性 PKA, and recombinant human alpha isoform of PKA 同种型 IgG 品种反应性 RatBovineHumanHamsterMousePig 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002730
Entrez基因汇总 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. 基因符号 - MGC48865
- PRKACA
- MGC102831
- PKACA
纯化方法 Protein A chromatography UniProt编号 - P17612
UniProt汇总 FUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
SIZE: 351 amino acids; 40590 Da
SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform 2 is sperm specific.
PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot on rat brain microsomal preparation or PC-12 RIPA cell lysates 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,672112,Urokinase, Human Urine
下一件merck millipore产品：merck millipore,默克密理博,676487,VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem
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