merck millipore,默克密理愽
  • merck millipore,默克密理博,662005,U0126 - CAS 109511-58-2 - Calbiochem

  • merck millipore,默克密理博,662005,U0126 - CAS 109511-58-2 - Calbiochem

    产品名称：U0126 - CAS 109511-58-2 - Calbiochem
    产品型号：662005
    A potent and specific inhibitor of MEK1 (IC₅₀ = 72 nM) and MEK2 (IC₅₀ = 58 nM).

    merck millipore,默克密理博,662005,U0126 - CAS 109511-58-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,662005,U0126 - CAS 109511-58-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₆N₆S₂•½C₂H₅OH109511-58-2
    描述
    概述 A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Shown to block doxazosin-induced osteoblastic differentiation. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Noncompetitive with respect to ATP. Also available in InSolution™ format (Cat. No. 662009).
    产品目录编号 662005
    品牌系列 Calbiochem®
    同义词 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene, MEK Inhibitor VI
    参考
    参考 Choi, Y.J., et al. 2011. Biochem. Biophys. Res. Commun. 416, 232.
    DeSilva, D.R., et al. 1998. J. Immunol. 160, 4175.
    Duncia, J.V., et al. 1998. Biorg. Med. Chem. Lett. 8, 2839.
    Favata, M.F., et al. 1998. J. Biol. Chem. 273, 18623.
    产品信息
    CAS号 109511-58-2
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₈H₁₆N₆S₂•½C₂H₅OH
    化学配方 C₁₈H₁₆N₆S₂•½C₂H₅OH
    Molar Mass 403.5
    可逆 N
    结构配方图像
    生物信息
    主靶 MEK1 and MEK2
    主靶IC50 72 nM, 58 nm, against MEK1, and MEK2, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Unstable in solution; reconstitute just prior to use.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,662005,U0126 - CAS 109511-58-2 - Calbiochem

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