merck millipore,默克密理博,475886,NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1

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merck millipore,默克密理博,475886,NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem
产品名称：NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem
产品型号：475886
Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.

merck millipore,默克密理博,475886,NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem

产品介绍

merck millipore,默克密理博,475886,NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem

重要规格表

经验配方	CAS号
C₇H₁₆N₄O₂ · CH₃CO₂H	53308-83-1

描述
概述	Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS; K_i = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
产品目录编号	475886
品牌系列	Calbiochem®
同义词	N^ω-Me-L-Arg, N^G-Me-L-Arg, AcOH, L-NMMA

参考
参考	Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170. O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311. Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651. Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438. Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177. Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664. Hibbs, J.B., et al. 1987. Science 237, 473. Palmer, R.M.J., et al. 1987. Nature 327, 524.

参考

Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
Hibbs, J.B., et al. 1987. Science 237, 473.
Palmer, R.M.J., et al. 1987. Nature 327, 524.

产品信息
CAS号	53308-83-1
具有ATP竞争性	N
形式	White solid
Hill配方	C₇H₁₆N₄O₂ · CH₃CO₂H
化学配方	C₇H₁₆N₄O₂ · CH₃CO₂H
Molar Mass	248.3
吸湿	Hygroscopic
可逆	N
结构配方图像

生物信息
主靶	eNOS
主靶K_i	700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS
纯度	≥99% by TLC; ≥99% by HPLC

理化信息
细胞可渗透	Y
溶解度	MeOH or H₂O

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+15°C to +30°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.