merck millipore,默克密理愽
  • merck millipore,默克密理博,654256,TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

  • merck millipore,默克密理博,654256,TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

    产品名称：TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem
    产品型号：654256
    The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

    merck millipore,默克密理博,654256,TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,654256,TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O1049741-03-8
    描述
    概述 A cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
    产品目录编号 654256
    品牌系列 Calbiochem®
    同义词 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor
    参考
    参考 He, M.M., et al. 2005. Science 310, 1022.
    产品信息
    CAS号 1049741-03-8
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
    化学配方 C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
    Molar Mass 629.6
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 TNF-α
    主靶IC50 22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,654256,TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-671,STK33 Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,ACK5010GS,Amicon Pro Affinity Concentration Kit GST with 10kDa Amicon Ultra-0.5 Device


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