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merck millipore,默克密理博,648493,TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem
产品名称：TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem
产品型号：648493
The TRPML Agonist, ML-SA1 controls the biological activity of TRPML. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,648493,TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₂H₂₂N₂O₃ 332382-54-4 描述 概述 A membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10 µM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1 µM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1 (Cat. No. 196000), a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells. 产品目录编号 648493 品牌系列 Calbiochem®
同义词 Mucolipin Synthetic Agonist 1, ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione 参考 参考 Shen, D., et al. 2012. Nat. Commun. 3, 731. 产品信息 CAS号 332382-54-4 形式 Off-white powder Hill配方 C₂₂H₂₂N₂O₃ Molar Mass 362.4 可逆 Y 结构配方图像 生物信息 主靶 TRPML1,2,3 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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