merck millipore,默克密理愽
  • merck millipore,默克密理博,454861,MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

  • merck millipore,默克密理博,454861,MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

    产品名称：MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem
    产品型号：454861
    The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>

    merck millipore,默克密理博,454861,MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,454861,MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₁H₉FN₆522629-08-9
    描述
    概述 A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
    产品目录编号 454861
    品牌系列 Calbiochem®
    同义词 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I, CGP 57380
    参考
    参考 Topisirovic, I., et al. 2004. Cancer Res. 64, 8639.
    Worch, J., et al. 2004. Oncogene 23, 9162.
    Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
    Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
    Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
    产品信息
    CAS号 522629-08-9
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₁₁H₉FN₆
    化学配方 C₁₁H₉FN₆
    Molar Mass 244.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 Mitogen-activated protein kinase-interacting kinase 1 (MNK1)
    主靶IC50 2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Toxic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,454861,MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

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