merck millipore,默克密理愽
  • merck millipore,默克密理博,645900,Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

  • merck millipore,默克密理博,645900,Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

    产品名称：Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem
    产品型号：645900
    A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

    merck millipore,默克密理博,645900,Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,645900,Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₄O₆38748-32-2
    描述
    概述 A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
    产品目录编号 645900
    品牌系列 Calbiochem®
    同义词 PG490
    参考
    参考 Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
    Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
    Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
    Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
    Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
    Yang, Y., et al. 1998. Immunopharmacology 40, 139.
    产品信息
    CAS号 38748-32-2
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₂₀H₂₄O₆
    化学配方 C₂₀H₂₄O₆
    Molar Mass 360.4
    可逆 N
    结构配方图像
    生物信息
    主靶 Activate DEVD-cleaving caspases
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    GHS安全信息
    RTECS YK7751000
    安全信息
    R相 R: 20/21/22-40

    Harmful by inhalation, in contact with skin and if swallowed.
    Limited evidence of a carcinogenic effect.
    S相 S: 22-36

    Do not breathe dust.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful & Carcinogenic / Teratogenic
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,645900,Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

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