merck millipore,默克密理愽
  • merck millipore,默克密理博,616464,InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

  • merck millipore,默克密理博,616464,InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

    产品名称：InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
    产品型号：616464
    The InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 controls the biological activity of TGF-β RI. Primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,616464,InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616464,InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₆N₄O₃ • 2H₂O301836-41-9
    描述
    概述 A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220). The solid form of this compound (Cat. No. 616461) is also available.
    产品目录编号 616464
    品牌系列 Calbiochem®
    参考
    参考 Ikushima, H., et al. 2009. Cell Stem Cell 5, 504.
    Lin, T., et al. 2009. Nat. Methods 6, 805.
    Maherali, N. and Hochedlinger, K., 2009. Curr. Biol. 19, 1718.
    Callahan, J.F., et al. 2002. J. Med. Chem. 45, 999.
    Inman, G.J., et al. 2002. Mol. Pharmacol. 62, 65.
    Laping, N.J., et al. 2002. Mol. Pharmacol. 62, 58.
    产品信息
    CAS号 301836-41-9
    形式 Liquid
    配方 A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO.
    Hill配方 C₂₂H₁₆N₄O₃ • 2H₂O
    化学配方 C₂₂H₁₆N₄O₃ • 2H₂O
    Molar Mass 420.4
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Irritant
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616464,InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

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