merck millipore,默克密理愽
  • merck millipore,默克密理博,616456,TGF-β RI Kinase Inhibitor V - CAS 627536-09-8 - Calbiochem

  • merck millipore,默克密理博,616456,TGF-β RI Kinase Inhibitor V - CAS 627536-09-8 - Calbiochem

    产品名称：TGF-β RI Kinase Inhibitor V - CAS 627536-09-8 - Calbiochem
    产品型号：616456
    The TGF-β RI Kinase Inhibitor V, also referenced under CAS 627536-09-8, controls the biological activity of TGF-β RI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphoryl More>>

    merck millipore,默克密理博,616456,TGF-β RI Kinase Inhibitor V - CAS 627536-09-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616456,TGF-β RI Kinase Inhibitor V - CAS 627536-09-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₀ClFN₆627536-09-8
    描述
    概述 A cell-permeable pteridine compound that blocks TGF-β signaling and displays anti-tumor properties. Acts as a potent, selective, and reversible inhibitor of TGF-β RI/ALK5 kinase (EC50 = 48 nM). It inhibits p38α, MAPKAP, PKD, and p38α only at much higher concentrations (≥867 nM), while exhibiting little activity aginst TGF-β RII, p38γ, JNK, ERK2, MAPKK6, PKA, or PKC even at concentrations as high as 50 µM. Inhibits TGF-β-mediated cellular functions both in vitro and in vivo.
    产品目录编号 616456
    品牌系列 Calbiochem®
    同义词 Transforming Growth Factor-β Type I Receptor Kinase Inhibitor V, 2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine, SD-208, ALK5 Inhibitor V
    参考
    参考 Ge, R., et al. 2006. Clin. Cancer Res. 12, 4315.
    Kapoun, A. M., et al. 2006. Mol. Pharmacol. 70, 518.
    Jian, H., et al. 2006. Genes Dev. 20, 666.
    Hayashi, T., et al. 2004. Clin. Cancer Res. 10, 7540.
    Uhl, M., et al. 2004. Cancer Res. 64, 7954.
    产品信息
    CAS号 627536-09-8
    具有ATP竞争性 N
    形式 Light yellow solid
    Hill配方 C₁₇H₁₀ClFN₆
    化学配方 C₁₇H₁₀ClFN₆
    Molar Mass 352.8
    可逆 Y
    结构配方图像
    生物信息
    主靶 TGF-β RI/ALK5 Kinase
    主靶IC50 EC50 = 48 nM against TGF-β RI/ALK5 kinase
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616456,TGF-β RI Kinase Inhibitor V - CAS 627536-09-8 - Calbiochem

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