merck millipore,默克密理愽
  • merck millipore,默克密理博,614852,Topoisomerase IIα Inhibitor, TSC24 - Calbiochem

  • merck millipore,默克密理博,614852,Topoisomerase IIα Inhibitor, TSC24 - Calbiochem

    产品名称：Topoisomerase IIα Inhibitor, TSC24 - Calbiochem
    产品型号：614852
    The Topoisomerase IIα Inhibitor, TSC24 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,614852,Topoisomerase IIα Inhibitor, TSC24 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,614852,Topoisomerase IIα Inhibitor, TSC24 - Calbiochem

    重要规格表

    经验配方
    C₁₃H₁₄N₄S
    描述
    概述 A cell-permeable, TSC (thiosemicarbazone) derivative that acts as a selective and ATP competitive Topoisomerase IIα inhibitor and Fe chelator. Independent of its Fe chelating ability, this compound is shown to block Topo II&alpha-catalyzed ATP hydrolysis by competing with ATP for binding to the ATPase domain of Topo IIα (Kd = 18 µM). It also displays M phase cell-cycle arrest at 1 µM in nocodazole-treated HT-29 cells. This compound demonstrates anti-proliferative activity, without distinct or obvious selectivity, towards HeLa, HL-60, SGC7901, and HT-29 cultures (IC50 = 90 nM, 50 nM, 30 nM, and 20 nM, respectively), and a broader panel of tumor cell lines with IC50 values in the nanomolar range.
    产品目录编号 614852
    品牌系列 Calbiochem®
    同义词 (E)-N,N-dimethyl-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide
    参考
    参考 Huang, H., et al. 2010. J. Med. Chem. 53, 3048.
    产品信息
    形式 Yellow powder
    Hill配方 C₁₃H₁₄N₄S
    化学配方 C₁₃H₁₄N₄S
    Molar Mass 258.34
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,614852,Topoisomerase IIα Inhibitor, TSC24 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,HTS141M,ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT5A Serotonin Receptor
下一件merck millipore产品：merck millipore,默克密理博,428201,LDN-211904 - Calbiochem


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