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merck millipore,默克密理博,428201,LDN-211904 - Calbiochem
产品名称：LDN-211904 - Calbiochem
产品型号：428201
LDN-211904 modulates the biological activity of EphB3 receptor tyrosine kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,428201,LDN-211904 - Calbiochem
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重要规格表
经验配方 C₂₁H₂₁ClN₄O₅ 描述 概述 A pyrazolo[1,5-a]pyridine derivative that acts as an potent and reversible EphB3 receptor tyrosine kinase inhibitor with an IC50 of 79 nM with good mouse liver microsomal stability and aqueous solubility. Shown to suppress EphB3-induced autophosphorylation of EphB3 receptor at 10 µM in cells. When profiled against a panel of 288 kinases at 5 µM, found to also inhibit most of the Eph (Erythropoietin-producing hepatocellular carcinoma) receptor kinases including EphA1, EphA2, EphA3, EphA4, EphA5, EphA8, EphB1, EphB2, EphB3, EphB4 and other tyrosine kinases, but not EphA6 and EphA7, and is non-inhibitory towards non-RTK kinases screened except for p38α, p38β, and Qik. 产品目录编号 428201 品牌系列 Calbiochem®
同义词 N-(2-chlorophenyl)-6-(piperidin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide oxalate, EphB3 inhibitor, LDN-211904 参考 参考 Qiao, L., et al. 2011, Bioorg. Med. Chem. Lett. 19, 6122 产品信息 形式 Off-white solid Hill配方 C₂₁H₂₁ClN₄O₅ 化学配方 C₂₁H₂₁ClN₄O₅ Molar Mass 444.87 可逆 Y 结构配方图像 生物信息 主靶 Erythropoietin-producing hepatocellular carcinoma (Eph) 主靶IC50 79 nM 纯度 ≥99% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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下一件merck millipore产品：merck millipore,默克密理博,AB5718,Anti-Hey L/HRT3 Antibody
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