merck millipore,默克密理博,614310,TLR3/dsRNA Complex Inhibitor

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Merck Millipore 默克密理愽

merck millipore,默克密理博,614310,TLR3/dsRNA Complex Inhibitor - Calbiochem

经验配方
C₁₈H₁₃ClFNO₃S

描述
概述	A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (K_i = 2.96 µM; K_d = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC₉₀ = 27 µM) and NO production (IC₅₀ = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC₅₀ >> 100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).
产品目录编号	614310
品牌系列	Calbiochem®
同义词	(R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

参考
参考	Cheng, K., et al. 2011. J. Am. Chem. Soc. 133, 3764.

生物信息
纯度	≥99% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,614310,TLR3/dsRNA Complex Inhibitor - Calbiochem

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