merck millipore,默克密理愽
  • merck millipore,默克密理博,574714,Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

  • merck millipore,默克密理博,574714,Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

    产品名称：Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem
    产品型号：574714
    The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylati More>>

    merck millipore,默克密理博,574714,Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,574714,Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₈N₆O₃ • HCl • H₂O732938-37-8
    描述
    概述 A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
    产品目录编号 574714
    品牌系列 Calbiochem®
    同义词 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
    参考
    参考 Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.
    产品信息
    CAS号 732938-37-8
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₂₀H₁₈N₆O₃ • HCl • H₂O
    化学配方 C₂₀H₁₈N₆O₃ • HCl • H₂O
    Molar Mass 444.9
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 Syk
    主靶IC50 10 nM
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,574714,Syk Inhibitor IV, BAY 61-3606 - CAS 732938-37-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,AG504,Human IgG2 kappa
下一件merck millipore产品：merck millipore,默克密理博,05-321,Anti-Phosphotyrosine Antibody, clone 4G10


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