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描述 产品目录编号 12-547 品牌系列 Upstate
商名 - Upstate
描述 JAK3tide 产品信息 演示 lyophilized 应用 应用 JAK3tide primarily used in Kinase Assays. 主要应用 - Kinase Assay
生物信息 Entrez基因编号 - NM_000215.2
Entrez基因汇总 JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). 基因符号 - JAK3_HUMAN
- JAK3
- LJAK
- L-JAK
- JAK-3
- JAKL
蛋白靶 JAK3 靶子系列 TK UniProt编号 - P52333
UniProt汇总 FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.
SIZE: 1124 amino acids; 125099 Da
SUBUNIT: Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.
SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).
TISSUE SPECIFICITY: In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins.
DOMAIN: SwissProt: P52333 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.
PTM: Tyrosine phosphorylated in response to IL-2 and IL-4.
DISEASE: SwissProt: P52333 # Defects in JAK3 are a cause of autosomal recessive T-cell negative/B-cell positive type of severe combined immunodeficiency (SCID) [MIM:600802]; a condition characterized by the absence of circulating mature T-lymphocytes and NK cells, normal to elevated numbers of nonfunctional B-lymphocytes, and marked hypoplasia of lymphoid tissues.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.产品使用声明 质量保证 Routinely evaluated as a substrate using JAK3, active (14-629) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at 4°C 包装信息 数量 1000 µg
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下一件merck millipore产品：merck millipore,默克密理博,07-549,Anti-trimethyl-Histone H3 (Lys36) Antibody
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