merck millipore,默克密理愽
  • merck millipore,默克密理博,574711,Syk Inhibitor - CAS 622387-85-3 - Calbiochem

  • merck millipore,默克密理博,574711,Syk Inhibitor - CAS 622387-85-3 - Calbiochem

    产品名称：Syk Inhibitor - CAS 622387-85-3 - Calbiochem
    产品型号：574711
    The Spleen Tyrosine Kinase Inhibitor, also referenced under CAS 622387-85-3, controls the biological activity of Spleen Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphoryla More>>

    merck millipore,默克密理博,574711,Syk Inhibitor - CAS 622387-85-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,574711,Syk Inhibitor - CAS 622387-85-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₅N₃O₃S622387-85-3
    描述
    概述 A cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC50 = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
    产品目录编号 574711
    品牌系列 Calbiochem®
    同义词 Spleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
    参考
    参考 Lai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.
    产品信息
    CAS号 622387-85-3
    具有ATP竞争性 Y
    形式 Deep orange solid
    Hill配方 C₁₈H₁₅N₃O₃S
    化学配方 C₁₈H₁₅N₃O₃S
    Molar Mass 353.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 Syk
    主靶IC50 14 nM; EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3
    纯度 ≥97% by HPLC (sum of two isomers)
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,574711,Syk Inhibitor - CAS 622387-85-3 - Calbiochem

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