- 当前位置:首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
经验配方 C₁₇H₁₂BrNO₅ 描述 概述 A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg). 产品目录编号 574661 品牌系列 Calbiochem®
同义词 Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one 参考 参考 Berezov, A., et al. 2011. Oncogene 31, 1938. 产品信息 形式 White solid Hill配方 C₁₇H₁₂BrNO₅ 化学配方 C₁₇H₁₂BrNO₅ Molar Mass 390.18 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品:merck millipore,默克密理博,ABD132,Anti-PHOX2B Antibody
下一件merck millipore产品:merck millipore,默克密理博,MAB416,Anti-Interferon-β Antibody, clone A1
merck millipore,默克密理博,AB1538,Anti-Dopamine β Hydroxylase Antibody, NT
merck millipore,默克密理博,14-783M,PI3 Kinase (p110α(E545K)/p85α), 250 µg
merck millipore,默克密理博,14-491,Histone H2B Protein, human recombinant, 100 µg
merck millipore,默克密理博,MAB1800,Anti-Cytochrome C Antibody, clone 7H8.2C12
merck millipore,默克密理博,ABD132,Anti-PHOX2B Antibody
merck millipore,默克密理博,MAB416,Anti-Interferon-β Antibody, clone A1
merck millipore,默克密理博,SF-1138,APOE; Rat, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MAB5212,Anti-Neurocan Antibody, clone 650.24
merck millipore,默克密理博,MAB8703,Anti-Dengue Virus Type III Antibody, clone 5D4-11
merck millipore,默克密理博,579053,InSolution™ TAPI-1 - Calbiochem



