• merck millipore,默克密理博,574661,Survivin Antagonist, S12 - Calbiochem
  • merck millipore,默克密理博,574661,Survivin Antagonist, S12 - Calbiochem

    产品名称:Survivin Antagonist, S12 - Calbiochem
    产品型号:574661
    The Survivin Antagonist, S12 controls the biological activity of Survivin.

    merck millipore,默克密理博,574661,Survivin Antagonist, S12 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,574661,Survivin Antagonist, S12 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₂BrNO₅
    描述
    概述 A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
    产品目录编号 574661
    品牌系列 Calbiochem®
    同义词 Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one
    参考
    参考 Berezov, A., et al. 2011. Oncogene 31, 1938.
    产品信息
    形式 White solid
    Hill配方 C₁₇H₁₂BrNO₅
    化学配方 C₁₇H₁₂BrNO₅
    Molar Mass 390.18
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,574661,Survivin Antagonist, S12 - Calbiochem

上一件merck millipore产品:merck millipore,默克密理博,ABD132,Anti-PHOX2B Antibody
下一件merck millipore产品:merck millipore,默克密理博,MAB416,Anti-Interferon-β Antibody, clone A1



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