merck millipore,默克密理博,574215,D,L-Sulforaphane - CAS 4478-93-7

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merck millipore,默克密理博,574215,D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem
产品名称：D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem
产品型号：574215
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

merck millipore,默克密理博,574215,D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

产品介绍

merck millipore,默克密理博,574215,D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

重要规格表

经验配方	CAS号
C₆H₁₁NOS₂	4478-93-7

描述
概述	An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
产品目录编号	574215
品牌系列	Calbiochem®
同义词	1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane

参考
参考	Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426. Yu, R., et al. 2000. J. Biol. Chem. 275, 2322. Yu, R., et al. 1999. J. Biol. Chem. 274, 27545. Barcelo, S., et al. 1998. Mutat. Res. 402, 111. Maheo, K., et al. 1997. Cancer Res. 57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.

参考

Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
Maheo, K., et al. 1997. Cancer Res. 57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.

产品信息
CAS号	4478-93-7
具有ATP竞争性	N
形式	Slight yellow liquid
Hill配方	C₆H₁₁NOS₂
化学配方	C₆H₁₁NOS₂
Molar Mass	177.3
可逆	N
结构配方图像

生物信息
主靶	Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
纯度	≥98% by UPLC

理化信息
细胞可渗透	N
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.