merck millipore,默克密理博,573106,STAT3 Inhibitor X, HJB

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Merck Millipore 默克密理愽

merck millipore,默克密理博,573106,STAT3 Inhibitor X, HJB - Calbiochem

经验配方
C₂₀H₂₆O₅

描述
概述	A diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC₅₀= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC₅₀ <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
产品目录编号	573106
品牌系列	Calbiochem®
同义词	17-Hydroxy-jolkinolide B, HJB

参考
参考	Wang, Y., et al. 2009, Canc. Res. 69, 7302.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,573106,STAT3 Inhibitor X, HJB - Calbiochem

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