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经验配方 C₁₀H₂₂Cl₆N₄O₆Pt 描述 概述 A cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.
Note: Carboplatin, Cisplatin, and other platinum drugs are reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Solubilization with DMSO prior to culture treatment is not recommended.产品目录编号 475851 品牌系列 Calbiochem®
同义词 c,c,t-[Pt(NH₃)₂Cl₂(O₂CCHCl₂)₂] 参考 参考 Hall, M.D., et al. 2014. Cancer Res. In press.
Dhar, S., and Lippard, S.J., 2009. Proc. Natl. Acad. Sci. USA 106, 22199.产品信息 形式 Off-white to cream solid Hill配方 C₁₀H₂₂Cl₆N₄O₆Pt 化学配方 C₁₀H₂₂Cl₆N₄O₆Pt Molar Mass 702.1 结构配方图像 生物信息 纯度 ≥95% by NMR 理化信息 溶解度 DMSO 安全信息 R相 R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.S相 S: 22-36-45
Do not breathe dust.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. Use only fresh DMSO for reconstitution. 包装信息 惰性气体下包装 Packaged under inert gas
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