merck millipore,默克密理愽
  • merck millipore,默克密理博,572888,SU1498 - Calbiochem

  • merck millipore,默克密理博,572888,SU1498 - Calbiochem

    产品名称：SU1498 - Calbiochem
    产品型号：572888
    A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC₅₀ = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.

    merck millipore,默克密理博,572888,SU1498 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,572888,SU1498 - Calbiochem

    重要规格表

    经验配方
    C₂₅H₃₀N₂O₂
    描述
    概述 A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase. Also reduces the expression of ets-1, a transcription factor stimulated by VEGF. Has only a weak inhibitory effect on PDGF-receptor (IC50 >50 µM), EGF-receptor (IC50 >100 µM), and HER2 (IC50 >100 µM) kinases. Acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay and in an in vivo VEGF-induced permeability assay.
    产品目录编号 572888
    品牌系列 Calbiochem®
    同义词 (E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile, VEGFR Tyrosine Kinase Inhibitor VIII, VEGFR2 Kinase Inhibitor X
    参考
    参考 Arbiser, J.L., et al. 2000. Am. J. Pathol. 156, 1469.
    Strawn, L.M., et al. 1996. Cancer Res. 56, 3540.
    产品信息
    具有ATP竞争性 Y
    形式 Pale yellow solid
    Hill配方 C₂₅H₃₀N₂O₂
    化学配方 C₂₅H₃₀N₂O₂
    Molar Mass 390.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 Flk-1 kinase
    主靶IC50 700 nM
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,572888,SU1498 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-327M,JNK1α1/SAPK1c Protein, active, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,575310,T0901317 - CAS 293754-55-9 - Calbiochem


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