merck millipore,默克密理博,569371,SREBP Processing Inhibitor, Betulin - CAS 473-98-3

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merck millipore,默克密理博,569371,SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem
产品名称：SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem
产品型号：569371
The SREBP Processing Inhibitor, Betulin, also referenced under CAS 473-98-3, controls the biological activity of SCAP (SREBP cleavage activating protein). This small molecule/inhibitor is primarily us More>>

merck millipore,默克密理博,569371,SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem

产品介绍

merck millipore,默克密理博,569371,SREBP Processing Inhibitor, Betulin - CAS 473-98-3 - Calbiochem

重要规格表

经验配方	CAS号
C₃₀H₅₀O₂	473-98-3

描述
概述	A cell-permeable pentacyclic triterpenoid from birch bark extract that interacts with SCAP (SREBP cleavage activating protein) and prevents SREBP (sterol regulatory element-binding protein) Golgi proteolytic activation (1 to 13.55 µM in Rat hepatocytes CRL-1601) via a similar mechanism as oxysterols by inducing the association of SCAP with Insig-1 (insulin-induced gene-1), thereby causing SCAP-SREBPs complex ER retention. Unlike oxysterols, Betulin does not activate LXR to induce concomitant HMGCR (HMG-CoA reductase) degradation and SREBP-1 up-regulation. While both Betulin and HMGCR inhibitor Lovastatin (Cat. No. 438185) inhibit cellular cholesterol synthesis (by ~70% in CRL-1601 cultures with respective compound at 13.55 and 1 µM concentration), only Betulin suppresses cellular fatty acid synthesis (by ~55% at 13.55 µM in CRL-1601). Betulin is shown to exhibit comparable in vivo efficacy as Lovastatin (both dosed at 30 mg/kg/day with chow) in ameliorating high fat/cholesterol diet-induced obesity (% fat/lean tissue ratio increase from non-fat diet mice = 167, 44, and 33 in mice consuming fat diet alone, with Lovastatin, with Betulin, respectively). However, only Betulin is demonstrated to lower fasting blood glucose and insulin levels and reduce fat cell size in white adipose tissue in high fat diet mice. Fatostatin (Cat. No. 341329) in comparison does not target SCAP via sterol-binding site, nor does it induce SCAP binding to Insig-1.
产品目录编号	569371
品牌系列	Calbiochem®
同义词	Lup-20(29)-ene-3β,28-diol, Sterol Regulatory Element Binding Protein Processing Inhibitor, Betulin

参考
参考	Tang, J.J., et al. 2011. Cell Metab. 13, 44.

产品信息
CAS号	473-98-3
形式	Off-white powder
Hill配方	C₃₀H₅₀O₂
化学配方	C₃₀H₅₀O₂
Molar Mass	442.7
结构配方图像

生物信息
纯度	≥95% by NMR

理化信息
溶解度	DMSO

安全信息
R相	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S相	S: 22-26-36 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Toxic
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.