merck millipore,默克密理愽
  • merck millipore,默克密理博,566224,Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem

  • merck millipore,默克密理博,566224,Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem

    产品名称：Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem
    产品型号：566224
    The Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac controls the biological activity of Sialyltransferase.

    merck millipore,默克密理博,566224,Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,566224,Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem

    重要规格表

    经验配方
    C₂₂H₃₀FNO₁₄
    描述
    概述 A cell-permeable sialylic acid analog that upon cellular uptake is transformed into a CMP-Neu5Ac (Cat. No. 233264) mimetic bearing a C3 fluorine substituent at the axial position, effectively inhibiting sialyltransferase in a donor substrate CMP-Neu5Ac-competitive manner. Shown to effectively abloishes HL-60 cell surface SLeX expression (by >95%; 200 µM for 5 days), resulting in dramatic reductions in cell surface E-selectin and P-selectin binding (by >95% and >80%, respectively), without affecting cell viability or proliferation.
    产品目录编号 566224
    品牌系列 Calbiochem®
    同义词 (1S,2R)-1-((3S,4R,5R,6S)-3-acetamido-4,6-diacetoxy-5-fluoro-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate, 3Fax-Neu5Ac Prodrug
    参考
    参考 Rillahan, C., et al. 2012. Nat. Chem. Bio. 8, 661.
    产品信息
    形式 White solid
    Hill配方 C₂₂H₃₀FNO₁₄
    Molar Mass 551.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 Sialyltransferase
    纯度 ≥98% by NMR
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 ≤ -70°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,566224,Sialyltransferase Inhibitor, 3Fax-Peracetyl Neu5Ac - Calbiochem

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