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  • merck millipore,默克密理博,06-1366,Anti-SRp55 Antibody

  • merck millipore,默克密理博,06-1366,Anti-SRp55 Antibody

    产品名称：Anti-SRp55 Antibody
    产品型号：06-1366
    Anti-SRp55 Antibody is a Rabbit Polyclonal Antibody for detection of SRp55 also known as serine/arginine-rich splicing factor 6, Pre-mRNA-splicing factor SRP55 & has been validated in WB & IP.

    merck millipore,默克密理博,06-1366,Anti-SRp55 Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1366,Anti-SRp55 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1366
    描述 Anti-SRp55 Antibody
    Alternate Names
    • SR splicing factor 6
    • serine/arginine-rich splicing factor 6
    • splicing factor, arginine/serine-rich 6
    • arginine/serine-rich splicing factor 6
    • splicing factor, arginine/serine-rich, 55 kDa
    • Pre-mRNA-splicing factor SRP55
    • pre-mRNA splicing factor SRP55
    背景信息 Pre-mRNA-splicing factor SRp55, also known as Serine/arginine-rich splicing factor 6, is a member of the serine/arginine-rich (SR) protein family. This group of proteins is found mainly in the nucleus where they play a critical role in regulated and constitutive splicing of precursor mRNAs. SRp55 is involved in the constitutive process for mRNA splicing, and is able to mediate alternative splice site selection. Considered one of the more ubiquitous of the splice factors, SRp55 is upregulated in response to DNA damage when p53 is lacking. SRp55 is significantly phosphorylated on RS domain serine residues.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-SRp55 Antibody is a Rabbit Polyclonal Antibody for detection of SRp55 also known as serine/arginine-rich splicing factor 6, Pre-mRNA-splicing factor SRP55 & has been validated in WB & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis:
    A representative lot was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human SRp55.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_006266
    Entrez基因汇总 The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.
    基因符号
    • B52
    • SRP55
    • SFRS6
    • SRSF6
    纯化方法 Protein A
    UniProt编号
    • Q13247
    UniProt汇总 FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

    SUBUNIT STRUCTURE: Binds SFRS12.

    SUBCELLULAR LOCATION: Nucleus.

    PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.

    Contains 2 RRM (RNA recognition motif) domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 1:500 dilution of this antibody detected SRp55 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,06-1366,Anti-SRp55 Antibody

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