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merck millipore,默克密理博,565793,γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
产品名称：γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
产品型号：565793
The γ-Secretase Inhibitor XXIV, BMS299897, also referenced under CAS 290315-45-6, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience appl More>>
merck millipore,默克密理博,565793,γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₁ClF₃NO₄S 290315-45-6 描述 概述 A cell-permeable sulfonamide compound that preferentially inhibits cellular γ-secretase cleavage of APP CTF over Notch-1 (IC50 = 7.1 and 105.9 nM, respectively) in a presenillin 1-/PS1-selective manner (IC50 = 8 and 308 nM against PS1 and PS2, respectively). BMS-299897 is shown to be orally available, readily cross blood-brain-barrier (<15 min), and effectively suppress plasma and brain Aβ level in human APP-bearing transgenic mice in a time- and dose-dependent manner (optimal p.o. dose 100 mg/kg) in vivo. 产品目录编号 565793 品牌系列 Calbiochem®
同义词 4-(2-((1R)-1-(((4-Chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic acid , BMS-299897, BMS 299897 参考 参考 Zhao, B., et al. 2008. J. Biol. Chem. 283, 2927.
Barten, D.M., et al. 2005. J. Pharmacol. Exp. Ther. 312, 635.
Anderson, J.J., et al. 2005. Biochem. Pharmacol. 69, 689.产品信息 CAS号 290315-45-6 形式 White solid Hill配方 C₂₄H₂₁ClF₃NO₄S 化学配方 C₂₄H₂₁ClF₃NO₄S Molar Mass 511.9 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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