- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,06-1067,Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody
产品名称：Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody
产品型号：06-1067
This Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody is validated for use in WB, IH(P), FC for the detection of Interleukin 10 Receptor Alpha (IL-10RA).
merck millipore,默克密理博,06-1067,Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, M FC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1067 描述 Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody Alternate Names - interleukin-10 receptor alpha chain
- CDw210a antigen
- interleukin 10 receptor, alpha
背景信息 Interleukin 10 receptor, alpha subunit (IL-10RA or CDW210A) is a subunit for the interleukin-10 receptor and a single-pass type I membrane protein. The IL-10 receptor complex contains two subunits, the ligand binding IL10RA and the IL10RB. IL-10RA has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibit the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. IL-10RA is found in spleen, thymus, and PBMCs and is highly expressed in monocytes, B-cells, large granular lymphocytes, and T-cells. IL-10RA is weakly expressed in pancreas, skeletal muscle, brain, heart, and kidney tissues, and intermediately expressed in placenta, lung, and liver tissue. 产品信息 格式 Affinity Purified 控制 - Human thymus lysate
演示 Purified rabbit polyclonal in PBS with 0.05% sodium azide. 应用 应用 This Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody is validated for use in WB, IH(P), FC for the detection of Interleukin 10 Receptor Alpha (IL-10RA). 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry Analysis: 5 µg of antibody from a previous lot detected IL-10RA in human PBMC's.
Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-10RA in mouse spleen tissue.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human IL-10RA. 表位 Cytoplasmic Domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the cytoplasmic domain of IL-10RA. 品种反应性 ChimpanzeeHumanMouse Species Reactivity Note Demonstrated to react with human and mouse.
Predicted to react with chimpanzee based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001549
Entrez基因汇总 The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq]. 基因符号 - IL10R
- IL10RA
- CDW210A
- HIL-10R
- IL-10R-A
- IL-10R1
纯化方法 Affinity Purfied UniProt编号 - Q13651
UniProt汇总 FUNCTION: Receptor for IL10; binds IL10 with a high affinity.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICTY: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.
SEQUENCE SIMLARITIES: Belongs to the type II cytokine receptor family.产品使用声明 质量保证 Evaluated by Western Blot in human thymus lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected IL-10RA on 10 µg of human thymus lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,AB9358,Anti-Neuropeptide Y2 Receptor Antibody
下一件merck millipore产品：merck millipore,默克密理博,565793,γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
相关产品
merck millipore,默克密理博,AG318,Acetylcholine Receptor-γ, control peptide for AB5936
merck millipore,默克密理博,MABF337,Anti-CD123 (human) Antibody, PE, clone 6H6
merck millipore,默克密理博,328005,ERK Activation Inhibitor Peptide II, Cell-Permeable - Calbiochem
merck millipore,默克密理博,MABE78,Anti-MiTF Antibody, clone 3D1.2
merck millipore,默克密理博,AB9358,Anti-Neuropeptide Y2 Receptor Antibody
merck millipore,默克密理博,565793,γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
merck millipore,默克密理博,GF156,B18R, Human Recombinant Carrier-Free
merck millipore,默克密理博,MABF338,Anti-IL-4 (human) Antibody, FITC, clone MP4-25D2
merck millipore,默克密理博,05-1478,Anti-RUNX2 Antibody, clone AS110
merck millipore,默克密理博,MAB1921,Anti-Laminin β1 Antibody, clone 4E10