merck millipore,默克密理愽
  • merck millipore,默克密理博,559286,RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

  • merck millipore,默克密理博,559286,RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

    产品名称：RSK Inhibitor II - CAS 501437-28-1 - Calbiochem
    产品型号：559286
    The RSK Inhibitor II, also referenced under CAS 501437-28-1, controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Cell Signaling applications.

    merck millipore,默克密理博,559286,RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,559286,RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₃F₂N₅O₂501437-28-1
    描述
    概述 The racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC50 ≤31 nM against RSK1, 2, 3, and 4; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC50 ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated HEK-293 cells and EGF-stimulated Rat-2 cells (IC50 ~1 µM).
    产品目录编号 559286
    品牌系列 Calbiochem®
    同义词 2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870
    参考
    参考 Carriere, A., et al. 2008. Curr. Biol. 18, 1269
    Sapkota, G.P., et al. 2007. Biochem. J. 401, 29.
    Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.
    产品信息
    CAS号 501437-28-1
    形式 Off-white solid
    Hill配方 C₁₉H₂₃F₂N₅O₂
    化学配方 C₁₉H₂₃F₂N₅O₂
    Molar Mass 391.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559286,RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

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