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merck millipore,默克密理博,554995,RGS Proteins Inhibitor II, CCG-50014 - Calbiochem
产品名称：RGS Proteins Inhibitor II, CCG-50014 - Calbiochem
产品型号：554995
The RGS Proteins Inhibitor II, CCG-50014 controls the biological activity of RGS4 proteins. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,554995,RGS Proteins Inhibitor II, CCG-50014 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₆H₁₃FN₂O₂S 描述 概述 A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50 = 0.03, 0.12, 3.5, 11, > 200 and > 200 µM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys− using FCPIA assay, respectively). Shown to block RGS4-Gα0 interaction and repress Gα0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Gα0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50 > 100 µM). A reversible inhibitor of RGS Proteins, CCG-63802 is also available (Cat. No. 554993). 产品目录编号 554995 品牌系列 Calbiochem®
同义词 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione 参考 参考 Blazer, L.L., et al. 2011. Biochemistry 50, 3181.
Roman, D.L., et al. 2009. J. Biomol. Screening 14, 610.产品信息 形式 White solid Hill配方 C₁₆H₁₃FN₂O₂S 化学配方 C₁₆H₁₃FN₂O₂S Molar Mass 316.4 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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